Pendahuluan: Kepatuhan terhadap five moments hand hygiene di rumah sakit, merupakan aspek penting dalam pencegahan healthcare associated infections (HAIs). Meskipun pedoman ini telah diterima secara luas, tingkat kepatuhan perawat terhadap five moments hand hygiene masih sering dilaporkan rendah di berbagai rumah sakit. Banyak faktor yang dapat mempengaruhi kepatuhan perawat terhadap five moments hand hygiene,tujuan dari penelitian ini diharapkan dapat ditemukan faktor faktor yang berhubungan dengan kepatuhan perawat dalam melakukan five moments hand hygiene. Metode: Design penelitian kuantitatif observasional non partisipan dengan pendekatan analitik cross sectional korelasi. Sampel yang digunakan dalam penelitian ini adalah perawat yang bekerja di RSUP Prof DR I.G.N.G Ngoerah dengan jumlah 334 sampel, data penelitian dikumpulkan dengan mengguanakan kuesioner, analisis data menggunakan univariate, bivariate dan multivariate. Hasil dan Analisis: Tingkat kepatuhan perawat melakukan five moments hand hygiene di RSUP Prof DR I.G.N.G Ngoerah mencapai 62,0%, faktor dominan yang berhubungan secara parsial dengan kepatuhan melakukan five moments hand hygiene yaitu: ruang perawatan (p 0,007; AOR: 2.116 ; 95% CI: 1,225 – 3,656 ), keyakinan (p 0,001; AOR : 16,596; 95% CI : 4,726 – 58,279), handscoon (p 0,001; AOR : 5,957; 95% CI : 3,430 – 10,340). Pembahasan dan kesimpulan: faktor dominan yang berpengaruh terhadap kepatuhan melakukan five moments hand hygiene adalah keyakinan, handscoon dan ruang perawatan. Selain faktor faktor yang dipakai dalam penelitian ini ada prediktor lain yang juga berpengaruh terhadap kepatuhan perawat melakukan five moments hand hygiene seperti situasi pasien, tingkat stressor, beban kerja dan sosial budaya. Kata kunci: Hand hygiene, five moments, Perawat.

Introduction: Compliance with the Five Moments Hand Hygiene in hospitals is an important aspect of preventing healthcare associated infections (HAIs). Although these guidelines have been widely accepted, nurses compliance with the five moments hand hygiene is still frequently reported as low in various hospitals. Several factors can influence nurses compliance with the five moments hand hygiene, and the aim of this study is to identify the factors related to nurses adherence to performing five moments hand hygiene. Method: A non-participant observational quantitative research design with an analytic cross-sectional correlation approach. The sample used in this study consisted of nurses working at RSUP Prof Ngoerah, with a total of 334 samples. Data was collected using a questionnaire, and data analysis was conducted using univariate, bivariate, and multivariate methods. Results and Analysis: The compliance rate of nurses performing the five moments of hand hygiene at RSUP Prof Ngoerah reached 62.0%. The dominant factors that are partially associated with adherence to the five moments of hand hygiene are: patient care area (p 0.007; AOR: 2.116; 95% CI: 1.225 - 3.656), belief (p 0.001; AOR: 16.596; 95% CI: 4.726 - 58.279), and hand glove use (p 0.001; AOR: 5.957; 95% CI: 3.430 - 10.340).Discussion and Conclusion: The dominant factors that influence adherence to the five moments of hand hygiene are beliefs, hand hygiene knowledge, and the care environment. In addition to the factors used in this study, there are other predictors that also affect nurses' adherence to the five moments of hand hygiene, such as patient condition, stress levels, workload, and socio-cultural factors. Keywords: Hand hygiene, five moments, nurses.