Latar Belakang: Penderita kanker, termasuk kanker payudara, mengalami peningkatan yang sangat signifikan dan berdampak pada kualitas hidup, seperti aspek psikologis, fisik, ekonomi, lingkungan sosial, dan hubungan interpersonal. Melalui perawatan paliatif membantu penderita menerima keadaannya sehingga memungkinkan tetap menjalani hidup meskipun dengan waktu terbatas, dengan fokus utama pada kualitas hidup, bukan kesembuhan. Tujuan: Untuk mengetahui kualitas hidup pasien kanker payudara dengan perawatan paliatif di ruang kemoterapi RSU Kertha Usada Buleleng. Metode: Desain penelitian ini adalah multiple case study dengan pendekatan deskriptif kualitatif pada 5 orang partisipan dengan kanker payudara yang dilakukan kemoterapi dengan perawatan paliatif. Metode pengumpulan data yang digunakan yaitu wawancara, observasi, dan dokumentasi. Hasil: Penderita kanker payudara pasca-mastektomi yang menjalani kemoterapi mengalami penurunan kualitas hidup. Perawatan paliatif membantu mengurangi rasa sakit dan meningkatkan kenyamanan, serta memenuhi kebutuhan partisipan. Kesimpulan: Keseluruhan partisipan tergolong dalam usia dewasa yang menderita kanker payudara stadium I – IV dan telah dilakukan pembedahan mastektomi yang kini sedang menjalani kemoterapi mengalami penurunan kualitas hidup. Kata Kunci: Kanker Payudara, Kualitas Hidup, Perawatan Paliatif

Background: Patients with cancer, including breast cancer, experience a very significant increase and have an impact on quality of life, such as psychological, physical, economic, social environment and interpersonal relationships. Through palliative care, it helps the patients to accept their situation so that it is possible to continue their life even with limited time, with the main focus on quality of life, not healing. Purpose: To describe the quality of life on breast cancer patients with palliative care in chemotherapy room at Kertha Usada Hospital Method: The research employed multiple case study with descriptive qualitative approach on 5 breast cancer patients who were done chemotherapy with palliative care. The methods of collecting data were interview, observation, and documentation. Findings: Patients with breast cancer post mastectomy who underwent chemotherapy had decline quality of life. Palliative care helped to reduce the pain, increase the comfort, and fulfil the patients’ needs. Conclusion: All of the participants are adult who have breast cancer stadium I-IV and have been done mastectomy and undergo chemotherapy have decline on quality of life. Key Words: Breast Cancer, Quality of Life, Palliative Care