Latar Belakang : Kesalahan pemberian obat (medication error) merupakan salah satu tantangan yang berdampak pada keselamatan pasien di fasilitas kesehatan. Implementasi Close Loop Medication Administration (CLMA) di Rumah Sakit Siloam Bali bertujuan meningkatkan keselamatan pasien dan efisiensi kerja. Persepsi dan kepuasan perawat terhadap penerapan CLMA menjadi faktor penting untuk keberhasilan sistem ini. Metode Penelitian : Penelitian ini menggunakan desain sequential explanatory mixed-method study dengan pendekatan kuantitatif diikuti analisis kualitatif. Survei kuantitatif dilakukan terhadap 99 perawat rawat inap menggunakan kuesioner terstruktur untuk menilai persepsi dan kepuasan. Wawancara mendalam dilakukan pada 15 perawat sebagai data pendukung kualitatif. Hasil Penelitian : Sebanyak 82% perawat memiliki persepsi positif terhadap CLMA, dengan skor tinggi pada aspek keamanan dan keakuratan pemberian obat. Sistem ini dinilai mempermudah pekerjaan perawat melalui fitur verifikasi otomatis dan pelacakan riwayat pemberian obat. Kepuasan perawat terhadap CLMA mencapai 76%, didorong oleh peningkatan efisiensi kerja dan penurunan beban administratif. Namun, terdapat hambatan pada proses integrasi antarunit, seperti farmasi dan dokter, serta kebutuhan pelatihan teknis yang lebih komprehensif. Hasil wawancara mengungkapkan bahwa meskipun sistem membantu menurunkan potensi medication error, beberapa perawat masih merasa terbebani oleh adaptasi awal terhadap teknologi baru. Kesimpulan : Penerapan CLMA memberikan dampak positif terhadap persepsi dan kepuasan perawat, terutama dalam meningkatkan keselamatan pasien dan efisiensi kerja. Kendala integrasi lintas profesi dan kebutuhan pelatihan lanjutan perlu menjadi perhatian untuk mengoptimalkan implementasi CLMA. Kata Kunci: Close Loop Medication Administration, persepsi perawat, kepuasan kerja, keselamatan pasien, mixed-method study.

Background : Medication errors are one of the challenges that significantly impact patient safety in healthcare facilities. The implementation of Close Loop Medication Administration (CLMA) at Siloam Bali Hospital aims to enhance patient safety and work efficiency. Nurses' perceptions and satisfaction with CLMA implementation are crucial factors for the system's success. Methods : This study employed a sequential explanatory mixed-method design, combining quantitative and qualitative approaches. Quantitative data were collected through a structured questionnaire administered to 99 inpatient nurses to assess their perceptions and satisfaction. In-depth interviews were conducted with 15 nurses as qualitative data to provide additional insights. Results : A total of 82% of nurses reported a positive perception of CLMA, with high scores in the aspects of safety and accuracy in medication administration. The system was perceived to ease nurses' tasks through automatic verification features and medication history tracking. Nurse satisfaction with CLMA reached 76%, driven by improved work efficiency and reduced administrative workload. However, challenges were identified in cross-unit integration processes, such as with pharmacy and physicians, and the need for more comprehensive technical training. Interview results revealed that while the system helped reduce potential medication errors, some nurses felt burdened by the initial adaptation to the new technology. Conclusion : The implementation of CLMA positively impacts nurses' perceptions and satisfaction, particularly in enhancing patient safety and work efficiency. Challenges related to interprofessional integration and the need for further training should be addressed to optimize the implementation of CLMA. Keywords: Close Loop Medication Administration, nurses' perception, job satisfaction, patient safety, mixed-method study.