Latar Belakang : Penyakit TB Paru sampai saat ini masih menjadi salah satu masalah kesehatan yang utama di dunia. Untuk mengatasi TB Paru penggunaan obat-obatan menjadi bagian pertama dalam pengobatan farmakologi. Akan tetapi masalah yang sering dialami pasien TB Paru rentan mengalami drop out sehingga meningkatkan kejadian Multi Drug Resistant (MDR-TB). Kepatuhan minum obat dapat dipengaruhi oleh berbagai faktor seperti self-efficacy, dimana jika pasien memiliki keyakinan diri yang tinggi akan memperkuat kebiasaannya setiap hari. Faktor lain yang mempengaruhi kepatuhan yaitu dukungan keluarga, dimana dukungan keluarga dapat menjadi faktor penting dalam penyembuhan dan pemulihan pasien dalam mengawasi kepatuhan dalam pengobatan. Tujuan : Untuk mengetahui hubungan antara self-efficacy dan dukungan keluarga dengan kepatuhan minum obat pasien tuberkulosis di Puskesmas II Denpasar Barat Metode : Desain penelitian ini adalah analitik korelasi dengan pendekatan cross-sectional. Besar sampel sebanyak 87 responden yang direkrut menggunakan teknik total sampling. Alat pengumpulan data yang digunakan berupa kuesioner TBSES (Tuberculosis Self-Efficacy Scale), kuesioner dukungan keluarga dan kuesioner Morisky Medication Adherence Scale (MMAS-8). Data diolah dengan menggunakan statistik korelasi Spearman-Rho. Hasil : Hasil uji Spearman-Rho didapatkan nilai p value

Background: Pulmonary Tuberculosis (TB) disease is still one of the main health problems in the world. In order to treat Pulmonary Tuberculosis, the use of drugs is the first part of pharmacological treatment. However, the problem that is often faced by patients with TB is they tend to drop out, so it increases the incidence of Multi Drug Resistant (MDR-TB). The compliance of taking medicine can be influenced by various factors such as self-efficacy, in which if the patients have high self-confidence, they will strengthen their habits every day. Another factor that influences compliance is family support. Family support can be an important factor in treating the patients and monitoring the compliance of taking medicine. Purpose: To determine the correlation between self-efficacy and family support toward the compliance of taking medicine on patients with tuberculosis at Public Health Center II West Denpasar. Method: This study employed analytical correlation design with cross sectional approach. There were 87 respondents recruited as the samples which were chosen by using total sampling technique. The instruments for collecting data were TBSES (Tuberculosis Self-Efficacy Scale), questionnaire, family support questionnaire, and Morisky Medication Adherence Scale (MMAS-8) questionnaire. The data were analysed by using Spearman rho test. Findings: The result showed that Ha was accepted which meant there was significant correlation between self-efficacy and the compliance of taking medicine (r=0.634) and family support toward compliance of taking medicine (r=0.712). Conclusion: The higher self-efficacy and family support, the more compliance of the patients when taking the medicine. The compliance of taking medicine is influenced by self-efficacy and family support. Keywords: Tuberculosis, Self-Efficacy, Family Support, Compliance of Taking Medicine