Latar Belakang : Infertilitas mempengaruhi sekitar 15-20% pasangan usia subur di Indonesia, termasuk di Bali dengan prevalensi mencapai 4,6%. Faktor penyebabnya beragam, mulai dari gangguan ovulasi, kelainan anatomi, masalah sperma hingga gaya hidup tidak sehat. In Vitro Fertilization (IVF) menjadi solusi utama bagi pasangan yang kesulitan memiliki anak. Tujuan : Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang mempengaruhi keberhasilan IVF di Klinik Royal IVF RSIA Bali Royal. Metode : Penelitian ini menggunakan desain analitik korelasi dengan pendekatan cross-sectional pada 160 pasangan yang mengikuti program bayi tabung di Klinik Royal IVF RSIA Bali Royal Tahun 2024. Data sekunder diambil dari rekam medis, dianalisa dengan menggunakan uji chi-square dengan signifikansi 0,05 Hasil : dari 160 pasangan, ditemukan bahwa usia, jenis infertilitas, kelainan tuba dan masalah sperma memiliki hubungan signifikan dengan keberhasilan program bayi tabung (p0,05). Kesimpulan : Keberhasilan program bayi tabung dipengaruhi secara signifikan oleh faktor usia, jenis infertilitas, kelainan tuba, dan masalah sperma. Sementara itu, gangguan ovulasi dan endometriosis tidak menunjukkan pengaruh yang signifikan terhadap keberhasilan bayi tabung. Kata Kunci : Bayi Tabung, Infertilitas, Usia Reproduksi, Kelainan Tuba, Masalah Sperma, Endometriosis, Gangguan Ovulasi, Keberhasilan IVF

Background: Infertility affects approximately 15–20% of couples on reproductive age in Indonesia, including in Bali in which the prevalence reaches 4.6%. The causes are varied such as ovulation disorders, anatomical abnormalities, sperm problems, and unhealthy lifestyles. In Vitro Fertilization (IVF) has become a primary solution for couples who struggle to have children. Purpose: To identify the factors associated to the success of IVF at Royal IVF Clinic of Bali Royal Hospital Method: This research employed analytical correlation design with cross sectional approach. The samples were 160 couples who followed In Vitro Fertilization program at Royal IVF Clinic of Bali Royal Hospital in 2024. The secondary data were taken from medical history and were analyzed by using chi-square test with significancy 0,05. Findings: The result showed out of 160 couples, there were found that age, infertility, fallopian tube abnormalities, and sperm problems had significant relationship with the success of in vitro fertilization (p0,05). Conclusion: The success of in vitro fertilization is influenced by age, infertility, fallopian tube abnormalities, and sperm problems. Meanwhile, ovulation disorder and endometriosis do not have significant relationship toward the success of in vitro fertilization. Keywords: In Vitro Fertilization, Infertility, Reproductive Age, Fallopian Tube Abnormalities, Endometriosis, Ovulation Disorder, The success of IVF