Latar Belakang: Hiperglikemi merupakan kondisi meningkatnya kadar glukosa darah yang dapat menimbulkan stres oksidatif, sehingga memengaruhi kualitas spermatozoa. Daun kecombrang (Etlingera elatior) diketahui memiliki kandungan antioksidan tinggi seperti asam klorogenat dan flavonoid quercetin yang berpotensi memperbaiki kualitas spermatozoa. Tujuan: Mengetahui efektivitas antioksidan ekstrak daun kecombrang terhadap kualitas spermatozoa mencit jantan (Mus musculus) dengan kondisi hiperglikemi, ditinjau dari motilitas, morfologi, jumlah, dan viabilitas spermatozoa. Metode: Penelitian eksperimental dengan rancangan post-test only control group design. Sampel berupa 32 ekor mencit jantan galur Swiss Webster, dibagi dalam 4 kelompok yaitu kontrol normal, perlakuan aloksan (150 mg/kg BB), perlakuan ekstrak daun kecombrang dengan dosis (100 mg/kg BB) dan perlakuan ekstrak daun kecombrang dengan dosis (150 mg/kg BB) peroral selama 35 hari. Parameter kualitas spermatozoa dilihat menggunakan mikroskop pembesaran 400x dan dianalisis statistik menggunakan uji ANOVA dan Post Hoc LSD. Hasil: Pemberian ekstrak daun kecombrang 100 mg/kg BB dan 150 mg/kg BB secara signifikan dapat menurunkan kadar glokosa darah. Ekstrak daun kecombrang 100 mg/kg BB dan 150 mg/kg BB secara signifikan meningkatkan kualitas spermatozoa yang ditandai dengan meningkatrnya motilitas, jumlah viabilitas, serta menurunnya morfologi abnormal. Kesimpulan: Ekstrak daun kecombrang (Etlingera elatior) 100 mg/kg BB dan 150 mg/kg BB memiliki efektivitas sebagai antioksidan dalam memperbaiki kualitas spermatozoa mencit jantan dengan hiperglikemi. Kata Kunci: Etlingera elatior, antioksidan, hiperglikemi, spermatozoa, mencit jantan.

Background: Hyperglycemia is a condition characterized by elevated levels of glucose in the blood, which may cause oxidative stress and negatively influence sperm quality. Torch ginger leaves (Etlingera elatior) are recognized for their high concentrations of antioxidants, including chlorogenic acid and quercetin flavonoids, which may enhance sperm quality. Purpose: To determine the antioxidant effectiveness of torch ginger leaves (etlingera elatior) in improving sperm quality of hyperglycemic male mice (mus musculus). Method: This study employed an experimental design with a post-test only control group approach. The sample consisted of 32 male Swiss Webster mice, divided into four groups namely normal control, alloxan-treated group (150 mg/kg BW), and two treatment groups receiving torch ginger leaf extract at doses of 100 mg/kg BW and 150 mg/kg BW orally for 35 days. Sperm quality parameters were examined under a microscope at 400x magnification and statistically analyzed using ANOVA and Post Hoc LSD tests. Result: The findings showed that the administration of Etlingera elatior leaf extract at doses of 100 mg/kg BW and 150 mg/kg BW significantly reduced blood glucose levels. Both doses also significantly improved sperm quality, as indicated by increased motility, viability, sperm count, and a reduction in abnormal morphology. Conclusion: Etlingera elatior leaf extract at doses of 100 mg/kg BW and 150 mg/kg BW is effective as an antioxidant in improving the sperm quality of hyperglycemic male mice. Keywords: Etlingera elatior, antioxidant, hyperglycemic, spermatozoa, male mice.