Latar Belakang : Luka bakar merupakan kerusakan jaringan kulit akibat paparan panas yang memerlukan penanganan tepat untuk mencegah infeksi dan mempercepat penyembuhan. Daun asoka (Ixora coccinea L.) diketahui mengandung senyawa aktif seperti flavonoid, saponin, tanin, alkaloid, dan triterpenoid yang berperan dalam proses penyembuhan luka. Penelitian ini bertujuan untuk mengetahui aktivitas gel antiluka bakar dari formulasi gel ekstrak etanol daun asoka pada tikus putih jantan galur Wistar. Tujuan : Tujuan penelitian meliputi evaluasi mutu fisik gel, pengaruh pemberian gel terhadap penyembuhan luka bakar, serta pengaruh terhadap angiogenesis, kerapatan kolagen, dan infiltrasi sel radang. Hasil : Ekstrak diperoleh melalui metode maserasi dengan pelarut etanol 96% dan diformulasikan menjadi sediaan gel dengan konsentrasi 1%, 2%, dan 4%. Gel diuji mutu fisiknya meliputi organoleptis, homogenitas, pH, viskositas, dan daya sebar. Sediaan kemudian diaplikasikan secara topikal pada luka bakar derajat II pada tikus selama 21 hari. Hasil penelitian menunjukkan gel ekstrak daun Asoka memiliki mutu fisik yang baik. Gel dengan konsentrasi 4% memberikan efektivitas penyembuhan luka terbaik, diikuti konsentrasi 2% dan 1%. Skor histopatologi pada kelompok 4% menunjukkan jaringan mendekati normal, ditandai dengan infiltrasi sel radang rendah, peningkatan angiogenesis, dan kerapatan kolagen tinggi. Kesimpulan : Gel ekstrak daun Asoka memenuhi mutu fisik sediaan topikal dan efektif mempercepat penyembuhan luka bakar, sehingga berpotensi dikembangkan sebagai alternatif pengobatan luka bakar yang alami. Kata kunci: Ixora coccinea, gel, luka bakar, mutu fisik, angiogenesis, kolagen, infiltrasi sel radang, histopatologi.

Background: Burns are skin tissue injuries caused by heat exposure which require proper treatment to prevent infection and accelerate healing. Ashoka leaves (Ixora coccinea L.) are known to contain active compounds such as flavonoids, saponins, tannins, alkaloids, and triterpenoids, which is its purpose is the wound healing process. The purpose of this research was to determine burns healing activity of an ethanol gel extract formulation of Ashoka leaves in male white Wistar rats. Purpose: To evaluate the physical quality of gel, the effect of gel application on burns healing, and its impact on angiogenesis, collagen density, and inflammatory cell infiltration Method: The extract was obtained by using the maceration method with 96% ethanol as the solvent and was formulated into gel preparations at concentrations of 1%, 2%, and 4%. The gel was determined the physical quality including organoleptic properties, homogeneity, pH, viscosity, and spread ability. The preparations were then topically applied to second-degree burns on rats for 21 days. Findings: The Ashoka leaves extract had good physical quality. The 4% concentration gel had the highest wound healing efficacy, followed by the 2% and 1% concentrations. Histopathological scores in group of 4% showed tissue structure approached to normal which is characterized by low inflammatory cell infiltration, increased angiogenesis, and high collagen density. Conclusion: The Ashoka leaves extract gel fulfil the physical quality standards for topical preparations and are effective in accelerating burns healing. So, it is potential to be developed as a natural alternative for burn treatment. Keywords: Ixora coccinea, gel, burns, physical quality, angiogenesis, collagen, cell infiltration, inflammation, histopathology