Latar Belakang: Hipertensi atau tekanan darah tinggi adalah suatu kondisi medis ketika tekanan darah seseorang melebihi batas normal, yaitu tekanan sistolik ≥140 mmHg dan diastolik ≥90 mmHg. Dari total populasi di seluruh dunia, tingkat hipertensi global adalah 22 % dan kurang dari seperlima pasien berusaha mengendalikan tekanan darahnya. Tatalaksana dalam mengendalikan tekanan darah dapat dengan terapi farmakologi yang dilakukan seumur hidupnya sehingga menimbulkan tanangan baru seperti kesesuaian terhadapat algoritme guideline, ketercapaian target terapi, timbulnys DRP ( Drug Related Problems ). Tujuan: Penelitian ini bertujuan untuk mengetahun profil penggunaan obat anti hipertensi pada pasien hipertensi di klinik Kimia Farma 34 Diponegoro periode Januari-Desember 2024. Metode: Penelitian ini menggunakan pendekatan observasional dengan metode cross-sectional dengan sampel pasien hipertensi di Klinik Kimia Farma 34 Diponegoro. Hasil: Hasil menunjukkan bahwa dari 232 pasien hipertensi di Klinik Kimia Farma 34 Diponegoro, mayoritas berjenis kelamin perempuan (54,3%) dan berusia

Background. Hypertension, or high blood pressure, is a medical condition in which an individual’s blood pressure exceeds the normal limit, defined as systolic pressure ≥140 mmHg and diastolic pressure ≥90 mmHg. Globally, the prevalence of hypertension is 22%, with fewer than one-fifth of patients actively managing their blood pressure. Pharmacological therapy is commonly used as lifelong treatment, posing challenges related to guideline conformity, target achievement, and the emergence of Drug-Related Problems (DRPs). Objective. The purpose of this study was to identify the profile of antihypertensive drug usage among hypertensive respondents at Kimia Farma 34 Diponegoro Clinic during January–December 2024. Method. This study employed an observational cross-sectional design involving 232 hypertensive respondents at Kimia Farma 34 Diponegoro Clinic. Data were collected through medical record review. Results. Findings indicated that 54.3% of respondents were female and 92.2% were under 60 years old, with chronic kidney disease (CKD) being the most frequent comorbidity (23.7%). The most commonly used drug was Amlodipine 5 mg (38.4%) from the Calcium Channel Blocker group. In this study, 81.8% of respondents had not achieved the target blood pressure, and 78.8% still had blood pressure ≥140/90 mmHg, based on JNC 8 guidelines. These results indicate the necessity of intensifying therapy and improving patient adherence education. Conclusion. The profile shows that most hypertensive respondents at Kimia Farma 34 Diponegoro Clinic used Calcium Channel Blockers, especially Amlodipine 5 mg. However, since the majority of respondents (81.8%) had not achieved target blood pressure according to JNC 8, dose and drug modification are required for more adequate management. Keywords: Hypertension, Antihypertensive Drug, Amlodipine, DRPs, JNC 8