Luka bakar derajat II memerlukan terapi efektif untuk mempercepat penyembuhan dan mencegah infeksi. Bioplacenton® sering digunakan, namun memiliki keterbatasan dalam menyerap eksudat dan regenerasi jaringan. Penelitian ini membuat kebaruan dengan mengembangkan gel ekstrak bunga kertas (Bougainvillea glabra), tanaman herbal yang kaya flavonoid, alkaloid, saponin, tanin, dan fenol yang berpotensi mempercepat penyembuhan luka. Penelitian ini bertujuan untuk mengetahui mutu fisik gel ekstrak bunga kertas (Bougainvillea glabra) dan aktivitas penyembuhan luka bakar derajat II melalui parameter makroskopik dan histopatologi. Penelitian eksperimental ini menggunakan desain post-test only control group pada 30 tikus putih jantan Galur Wistar yang dibagi menjadi enam kelompok, termasuk kontrol negatif, positif (Bioplacenton®), dan perlakuan gel 0,5%, 1%, serta 2%. Parameter yang diamati meliputi penyembuhan luka dan histopatologi (infiltrasi sel radang, angiogenesis, pembentukan kolagen). Data dianalisis dengan uji Shapiro-Wilk, Levene, ANOVA, Kruskal-Wallis, post hoc Bonferroni dan Mann-Whitney. Gel ekstrak bunga kertas konsentrasi 2% memiliki mutu fisik yang baik sesuai SNI dan memberikan efek signifikan dalam mempercepat penyembuhan luka, meningkatkan angiogenesis dan pembentukan kolagen, serta menurunkan infiltrasi sel radang. Gel ekstrak konsentrasi 2% berpotensi sebagai alternatif terapi topikal alami yang efektif untuk penyembuhan luka bakar derajat II baik secara makroskopik maupun mikroskopik. Kata Kunci: Bougainvillea glabra, gel, luka bakar derajat II, penyembuhan luka, histopatologi.

Second-degree burns require an effective therapy to accelerate healing and prevent infection. Bioplacenton® is commonly used, however it has limitations in exudate absorption and tissue regeneration. This study introduces a novelty by developing a gel formulated from paper flower extract (Bougainvillea glabra), a herbal plant which is rich in flavonoids, alkaloids, saponins, tannins, and phenols and has the potential to accelerate wound healing. To determine physical gel of paper flower (Bougainvillea glabra) extract and the activity in healing second degree burns by using macroscopic and histopathology. This experimental study employed a posttest only control group design involving 30 male white Wistar rats, which were divided into six groups: negative control, positive control (Bioplacenton®), and the experimental groups received gel formulations at concentrations of 0.5%, 1%, and 2%. The observed parameters included wound healing and histopathological assessments (inflammatory cell infiltration, angiogenesis, and collagen formation). Data were analysed by using the Shapiro-Wilk test, Levene’s test, ANOVA, Kruskal-Wallis test, and post hoc analyses with Bonferroni and Mann-Whitney tests. The result showed that gel containing 2% paper flower extract had good physical quality according to Indonesian National Standards (SNI) and provided significant effects in accelerating wound healing, enhancing angiogenesis and collagen formation, as well as reducing inflammatory cell infiltration. The gel with extract concentration of 2% has potential as an alternative for natural topical therapeutic in second-degree burns healing, both macroscopically and microscopically. Keywords: Bougainvillea glabra, gel, burns, healing, histopathology