Latar Belakang: Luka sayat adalah jenis luka terbuka yang umum terjadi dan membutuhkan penanganan yang tepat. Bunga dan daun cengkeh ( S y z y giu m a r o m a tic u m L.) diketahui mengandung senyawa aktif seperti eugenol, flavonoid, tanin, dan saponin yang berpotensi mempercepat prosespenyembuhanluka. Tujuan: Untuk mengetahui perbandingan aktivitas sediaan krim bunga dan krim daun cengkeh ( S y z y giu m a r o m a tic u m L.) terhadap penyembuhan lukasayatpadatikusputihjantan( R a t t u s n o r v e gic u s ). Metode: Penelitian ini merupakan t r u e e x p e rim e n t al dengan desain p o s t t e s t o nly c o n t r ol g r o u p . Hewan uji dibagi dalam 4 kelompok: kontrol negatif (basis krim), kontrol positif (Bionect®), perlakuan 1 (krim bunga cengkeh 20%), & perlakuan 2 (krim daun cengkeh 20%). Pengamatan berlangsung selama 21 hari dengan pengukuran panjang luka setiap tiga hari. Data dianalisis menggunakan SPSS Statistics 30 dengan uji O n e W a y A N O V A , dilanjutkan dengan uji P o s t H o c L S D untuk melihat perbedaan antarkelompok. Hasil: Rata-rata luka menunjukkan penutupan sempurna pada hari ke-12, sehingga analisis statistik dilakukan hingga hari ke-9 saja. Pada hari tersebut, tidak ditemukan perbedaan yang bermakna antara kelompok krim bunga cengkeh, krim daun cengkeh, & kontrol positif (p>0,05), serta tidak terdapat perbedaan yang signifikan antara kelompok krim bunga cengkeh&krimdauncengkeh. Kesimpulan:Sediaankrimbunga&krimdauncengkehmemilikiefektivitas yang setara serta menunjukkan aktivitas yang tidak jauh berbeda dalam mempercepatpenyembuhanlukasayat. Kata Kunci: Krim bunga cengkeh, krim daun cengkeh, luka sayat, penyembuhanluka, S y z y giu m a r o m a tic u m L.

Background: An incised wound is a common type of open wound that requires proper management. Clove flowers and leaves ( S y z y giu m a r o m a tic u m L.) contain active compounds such as eugenol, flavonoids, tannins, and saponins which have potential to accelerate the wound healingprocess. Purpose: To compare the wound healing activity of clove flower cream and clove leaves cream ( S y z y giu m a r o m a tic u m L.) on incised wounds in malewhiterats( R a t t u s n o r v e gic u s ). Method: This research employed true experimental research with a posttest only control group design. The test animals were divided into four groups: negative control (cream base), positive control (Bionect®), treatment 1 (20% clove flower cream), and treatment 2 (20% clove leaves cream). The observations were conducted during 21 days with wound length were measured every three days. The data were analysed by using SPSS Statistics 30 with a One-Way ANOVA test, followed by a Post Hoc LSDtesttoidentifydifferencesbetweengroups. Findings: The result showed that the average wound showed complete closure by day-12. Therefore, the statistical analysis was conducted only until day-9. On that day, there were no significant differences between the clove flower cream, clove leaves cream, and positive control groups (p > 0.05), and there was also no significant difference between the clove flowercreamandcloveleavescreamgroups. Conclusion: The clove flower cream and clove leaves cream formulation have the similar effectiveness and similar activity in accelerating incised woundhealing. Keywords: Clove Flower Cream, Clove Leaves Cream, Incised Wound, WoundHealing, S y z y giu m a r o m a tic u m L.